
α– Lipoic acid
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α– Lipoic acid
α- Lipoic acid is light yellow powder crystal, almost tasteless. The solubility in water is small, about 1 g/L (20 ° C). It is soluble in 10% NaOH solution and aliphatic solvent. It is soluble in methanol, ethanol, chloroform and ether.
Lipoic acid α- Lipoic acid.
Since lipoic acid has a chiral center, it has two configurations: R and S.
Natural lipoic acid is a white crystal with only R configuration, and only R configuration lipoic acid can be covalently conjugated to lysine residues through amide bonds to play the role of coenzyme.
However, the synthetic lipoic acid is a mixture of equal proportion of R and S configurations, which is a light yellow powdery substance, and is extremely soluble in lipid solvents.
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